Abstract
1/2023
Case report
Increased maternal phenylalanine concentration may influence not only fetal heart structural development but also cardiovascular function and pulmonary tissue development in humans – a case report
Oskar Sylwestrzak
1
,
Julia Murlewska
1
,
Łukasz Sokołowski
1
,
Monika Tadros-Zins
2
,
Michał Krekora
2
,
Iwona Maroszyńska
3
,
Maria Respondek-Liberska
1, 4
- Department of Prenatal Cardiology, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
- Department of Obstetrics and Gynaecology, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
- Department of Neonatal Intensive Care and Congenital Malformation in Neonates and Infants, Polish Mother’s Memorial Hospital – Research Institute in Lodz, Poland
- Department of Diagnoses and Prevention of Fetal Malformations, Medical University of Lodz, Poland
Prenat Cardio 2023; 13 (1): 43-46
Online publish date: 2024/02/19
A case of the fetus exposed to elevated phenylalanine concentration, who presented structural and functional cardiovascular changes and pulmonary injury in uncontrolled phenylketonuria of the pregnant woman. Continued fetal echocardiographic monitoring in the third trimester of pregnancy allowed to present fetal functional cardiovascular abnormalities and suspect neonatal persistent pulmonary hypertension. To the best of our knowledge, prenatal detection of persistent pulmonary hypertension in the case of maternal phenylketonuria on the newborn has not been reported before, and increased phenylalanine might be an additional factor influencing pulmonary tissue development.
Keywords
case report, pulmonary hypertension, fetal echocardiography, fetal, phenylketonuria
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