Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe

Anna Wędrychowicz; Mari Minasyan; Alicja Pietraszek; Janusz Centkowski; Maria Stręk; Joanna Różańska; Kamila Chełmecka; Barbara Zdzierak; Marcelina Wilk; Patrycja Czekańska; Peter Pacut; Zofia Grzenda-Adamek; Jadwiga Małek; Marta Ciechanowska; Małgorzata Stelmach; Joanna Nazim; Jerzy B. Starzyk

doi:10.5114/pedm.2020.103113

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Original paper

Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe

Anna Wędrychowicz

^{1, 2}

,

Mari Minasyan

³

,

Alicja Pietraszek

³

,

Janusz Centkowski

³

,

Maria Stręk

³

,

Joanna Różańska

³

,

Kamila Chełmecka

³

,

Barbara Zdzierak

³

,

Marcelina Wilk

³

,

Patrycja Czekańska

³

,

Peter Pacut

³

,

Zofia Grzenda-Adamek

⁴

,

Jadwiga Małek

²

,

Marta Ciechanowska

²

,

Małgorzata Stelmach

²

,

Joanna Nazim

^{1, 2}

,

Jerzy B. Starzyk

³

Department of Endocrinology of Children and Adolescents, Jagiellonian University Collegium Medicum, Institute of Pediatrics, Krakow, Poland

Department of Endocrinology of Children and Adolescents, University Children’s Hospital in Krakow, Poland

Student Science Circle, Department of Endocrinology of Children and Adolescents, Jagiellonian University Collegium Medicum, Institute of Pediatrics, Krakow, Poland

Department of Pediatrics, Gastroenterology and Nutrition, University Children’s Hospital in Krakow, Poland

Pediatr Endocrinol Diabetes Metab 2021; 27 (1): 1–6

DOI: https://doi.org/10.5114/pedm.2020.103113

Online publish date: 2021/02/11

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AMA

Wędrychowicz A, Minasyan M, Pietraszek A, et al. Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe. Pediatric Endocrinology Diabetes and Metabolism. 2021;27(1):1-6. doi:10.5114/pedm.2020.103113.

APA

Wędrychowicz, A., Minasyan, M., Pietraszek, A., Centkowski, J., Stręk, M.,  & Różańska, J. et al. (2021). Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe. Pediatric Endocrinology Diabetes and Metabolism, 27(1), 1-6. https://doi.org/10.5114/pedm.2020.103113

Chicago

Wędrychowicz, Anna, Mari Minasyan, Alicja Pietraszek, Janusz Centkowski, Maria Stręk, Joanna Różańska,  and Kamila Chełmecka et al. 2021. "Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe". Pediatric Endocrinology Diabetes and Metabolism 27 (1): 1-6. doi:10.5114/pedm.2020.103113.

Harvard

Wędrychowicz, A., Minasyan, M., Pietraszek, A., Centkowski, J., Stręk, M., Różańska, J., Chełmecka, K., Zdzierak, B., Wilk, M., Czekańska, P., Pacut, P., Grzenda-Adamek, Z., Małek, J., Ciechanowska, M., Stelmach, M., Nazim, J.,  and B. Starzyk, J. (2021). Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe. Pediatric Endocrinology Diabetes and Metabolism, 27(1), pp.1-6. https://doi.org/10.5114/pedm.2020.103113

MLA

Wędrychowicz, Anna et al. "Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe." Pediatric Endocrinology Diabetes and Metabolism, vol. 27, no. 1, 2021, pp. 1-6. doi:10.5114/pedm.2020.103113.

Vancouver

Wędrychowicz A, Minasyan M, Pietraszek A, Centkowski J, Stręk M, Różańska J et al. Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe. Pediatric Endocrinology Diabetes and Metabolism. 2021;27(1):1-6. doi:10.5114/pedm.2020.103113.

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Introduction
The aim of our study was to analyze the incidence and the clinical characteristic of celiac disease (CD) in pediatric population with type 1 diabetes mellitus (T1DM).

Material and methods
The data of 880 patients with T1DM, 429 girls, mean age 12.14 ±4.0 years was retrospectively retrieved from medical records. Patients with T1DM and CD were selected and a detailed analysis of CD prevalence and its clinical characteristic at the time of CD diagnosis was performed. The data were compared with the previous data from our center published a decade ago.

Results
CD was suspected in 85/880 patients (9.65%) on the base of results of serological tests, but finally CD was diagnosed in 73/880 patients with T1DM (8.3%), in 53/429 girls (12.3%) and in 20/451 boys (4.4%). Most patients (71%) had CD diagnosed after T1DM onset. The majority of CD patients (72%) was asymptomatic. The CD diagnosis was not associated with inappropriate metabolic control of diabetes. The onset age of diabetes in children with CD was significantly lower than in those without CD (5.8 ±3.6 years vs. 7.56 ±4.0 years, p = 0.04). The prevalence of CD is significantly higher than a decade ago in our center (8.3% vs. 5.7%, p = 0.001).

Conclusions
In light of increasing prevalence of mainly asymptomatic CD in patients with T1DM, CD screening is necessary. However positive serological tests, which are currently used in screening, and are the first step of diagnostics, in some patients allow only to suspect the CD and further diagnostic steps should be performed.

keywords:

Increased prevalence of celiac disease and its clinical picture among patients with diabetes mellitus type 1 – observations from a single pediatric center in Central Europe

incidence, children and adolescents, type 1 diabetes mellitus, celiac disease, signs and symptoms