One of the most significant causes of infective endocarditis is a lack of hygiene in the oral cavity. The diversity of the possible clinical course dependent on the primary location of the disease and the extension to other organs require personalised and multidisciplinary treatment. We present 53-year-old patient admitted to the hospital with recurrent fever and left lower extremity pain. Ultrasound of the left groin showed a structure that seemed like a haematoma. Based on positive blood culture and bacterial vegetation on the tricuspid valve shown in echocardiography, infective endocarditis was diagnosed. Antibiotics by antibiogram were enabled with no clinical effect. Additionally, computed tomography of the left groin was performed, which visualised an abscess surrounding a vascular prosthesis implanted 2 years earlier. Four-week antibiotic treatment preceded by replacing the infected prosthesis with a saphenous vein graft was commissioned. Clinical improvement and lowering of C-reactive protein were observed. The presented case is to show the route of therapy for complicated infected endocarditis.