eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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vol. 16
Original paper

Institutional experience of paediatric high-grade central nervous system tumours: An analysis of 74 patients and review of the literature

Faruk Guclu Pinarli
Aynur Oguz
Ceyda Karadeniz
Arzu Okur
Avni Sarac
Kemali Baykaner
Huseyin Bora
Aylar Poyraz

Wspolczesna Onkol 2012; 16 (1): 26–33
Online publish date: 2012/02/29
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Aim of the study: Although the survival for children with certain central nervous system (CNS) tumour types has improved through current surgical and adjuvant treatment modalities, the prognosis of many high-grade tumours remains poor despite aggressive treatment. The aim of this study is to analyse patients with high-grade brain tumours in our institution to determine the histopathology, clinical characteristics, treatment modalities, and survival.

Material and methods : A total of 74 patients with a diagnosis of high-grade brain tumour were analysed. There were a total of 31 patients with embryonal tumours, 27 patients with high-grade glial tumours, 12 patients with brain stem gliomas and 4 patients with other high-grade brain tumours.

Results : There were 48 (65%) boys and 26 (35%) girls (ratio: 1.85) with a median age of 99.7 months (range = 2-204 months). The median follow-up period was 19 months (range = 1-204 months). Tumour recurrence was observed in 38 patients (51.4%). The overall survival rate and event-free survival rate of our patients were 27% and 19.5%, respectively.

Conclusions : Pediatric high-grade CNS tumours have a very aggressive behaviour and a significant number of children eventually succumb to disease despite multimodal treatment. There is a need of more effective therapeutic approaches for these tumours with poor prognosis. The future improvement in childhood high-grade brain tumour management depends on a better understanding of the molecular genetics and biology of brain tumours.

CNS cancers, paediatric oncology, survival, chemotherapy, medulloblastoma, glioma

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