Integrin inhibitors in cancer treatment

Janusz Rolski; Maciej Niemiec

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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8/2008
vol. 12

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abstract:

Integrin inhibitors in cancer treatment

Janusz Rolski

,

Maciej Niemiec

Współczesna Onkologia (2008) vol. 12; 8 (374–379)

Online publish date: 2008/12/05

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Integrins are the transmembrane proteins involved in intercellular communication and in the contact of cells with extracellular matrix. They are present in healthy and cancer cells as well. They are important in many processes: among other things, thrombosis, angiogenesis and in the metastasis of the neoplastic cells. This article summarizes current knowledge of integrin inhibitors in cancer treatment. All the available studies prove that they have the restrained toxicity and anticancer activity. Introducing them to the standard clinical practice needs further intensive studies.

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Integrin inhibitors in cancer treatment

Janusz Rolski , Maciej Niemiec

integrins, angiogenesis inhibitors, cell adhesion molecules

Janusz Rolski

,

Maciej Niemiec