We present the case report of a kidney transplant recipient, human immunodeficiency virus negative, man with Kaposi sarcoma. Clinically red-purple coloured papules and macules of different size were visible on the left foot. According to histopathology and immunohistochemistry, the picture was consistent with Kaposi sarcoma. In the treatment of Kaposi sarcoma it is of importance to control the levels of immunosuppressants. The reduction in the dose of tacrolimus adversely affected the functions of kidneys and the patient needed dialysis. Tacrolimus was replaced by everolimus. While the functions of the kidneys were stabilizing, the new areas of Kaposi sarcoma appeared, but the ache and oedema were relieved. In our patient it was impossible to discontinue immunosupression because of the patients comorbidities.