eISSN: 2450-5722
ISSN: 2450-5927
Journal of Health Inequalities
Current issue Archive Online first About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
 
1/2020
vol. 6
 
Share:
Share:
more
 
 
abstract:
Original paper

Level of selected pro-inflammatory markers in middle-aged women with Hashimoto’s disease

Joanna Szczepanik
1
,
Sławomir Graczyk
2
,
Katarzyna Domaszewska
2, 3

1.
Nutrition Clinic Vitamin, Poznan, Poland
2.
Faculty of Health Sciences, The President Stanislaw Wojciechowski State University of Applied Sciences in Kalisz, Poland
3.
Department of Physiology and Biochemistry, Poznan University of Physical Education, Poland
J Health Inequal 2020; 6 (1): 75-78
Online publish date: 2020/06/23
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
PlumX metrics:
Introduction
Hashimoto’s disease is an autoimmune disease in which the body produces antibodies against its own tissues, in this case against thyrocytes. Autoimmune diseases are associated with impaired immune tolerance. The aim of this study was to analyse selected pro-inflammatory markers in women with Hashimoto’s (HT) autoimmune thyroiditis compared to a group of healthy women.

Material and methods
In this research study 41 women with HT were compared with 30 healthy women. The content of immunological markers was assessed in blood serum by enzyme-linked ELISA methods. Cytokine IL-1ß, IL-6, and TNF-a were assessed.

Results
The concentration of IL-1β for women with HT was 3.1 (1.8-4.9) pg/ml, and for healthy women 1.0 (0.1-1.9) pg/ml. The concentration of IL-6 for women with HT was 12.1 (6.7-19.4) pg/ml, and for healthy women 3.8 (2.5-6.7) pg/ml. TNF-a concentration was higher for people with HT, at 3.4 (2.0-4.4) pg/ml, compared to healthy women, who had a level of 2.2 (1.2-3.4) pg/ml), but without significant statistical differences.

Conclusions
In HT we observe an increased immune response associated with an elevated concentration of pro-inflammatory cytokines.

keywords:

interleukin 1 (IL-1β), interleukin 6 (IL-6), human tumour necrosis factor alpha (TNF-a), Hashimoto disease

Quick links
© 2023 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.