Abstract
Maculopapular Cutaneous Mastocytosis: a Case Report with Particular Emphasis on Management
Department of Dermatology and Venereology, Medical University of Bialystok, Poland
Dermatol Rev/Przegl Dermatol 2026, 113, 41–46
Introduction
Mastocytosis is a heterogeneous disease characterized by abnormal proliferation and accumulation of mast cells in the skin and internal organs. Maculopapular cutaneous mastocytosis is the most common subtype and is characterized by pigmented skin lesions and a positive Darier’s sign.
Case report
A 45-year-old woman with a history of multiple allergies was admitted to the Dermatology Clinic for diagnostic evaluation and treatment of skin lesions that had appeared after the age of 20 and had gradually worsened over several years. Small, oval, pink-brown maculopapular lesions were observed on the upper trunk and proximal extremities. Laboratory tests revealed an elevated tryptase level of 16.7 µg/l (reference range: 5.0–11.0 µg/l). Histopathological examination of a skin biopsy confirmed cutaneous mastocytosis. Treatment with bilastine and prednisone resulted in clinical improvement. Continued follow-up was recommended.
Conclusions
Management of mastocytosis is long-term and requires patient education regarding the nature of the disease, exacerbating factors, and adherence to pharmacological therapy. Further diagnostic evaluation for systemic mastocytosis is recommended.
Keywords
mastocytosis, maculopapular cutaneous mastocytosis, tryptase, anaphylaxis
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