Abstract
6/2005
vol. 22
Matrix metalloproteinases and adamalisyns in pathomechanism of pemphigoid
PDiA 2005; XXII, 6: 283-287
Online publish date: 2005/12/28
Matrix metalloproteinases (MMPs) are members of a large family of enzymes that can degrade extracellular matrix (ECM). Matrix metalloproteinases and a specific adamalisyns participate in a broad variety of normal and pathologic states and recent evidence implicates the MMP family as potential mediators of remodeling and degradation of extracellular matrix. The abnormal regulation of MMPs and specific inhibitors of metalloproteinases (TIMPs) expression may cause destruction of tissue in some diseases. There is some evidence activity of metalloproteinases is elevated in pathogenesis of bullous diseases in which they play, perhaps, a crucial role in blisters formation.
Keywords
metalloproteinases, adamalisyns, tissue inhibitors of metalloproteinases, pemphigoid
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