Ménière’s disease – recent literature studies on its origin

Piotr Dąbrowski; Krzysztof Szyfter

eISSN: 2084-9842
ISSN: 1643-9279

Postępy w chirurgii głowy i szyi/Advances in Head and Neck Surgery

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2/2021
vol. 20

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abstract:

Review paper

Ménière’s disease – recent literature studies on its origin

Piotr Dąbrowski

¹

,

Krzysztof Szyfter

²

Katedra Otolaryngologii i Onkologii Laryngologicznej, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Instytut Genetyki Człowieka, PAN w Poznaniu

Postępy w Chirurgii Głowy i Szyi 2021; 2: 17–21

Online publish date: 2021/12/31

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Etiology of Ménie`re’s disease recognized over 150 years ago and known as pathology of inner ear has still not been sufficiently explained. The key symptoms include recurrent vertigo, tinnitus and fluctuating hearing loss and ear fullness. Biological studies on its pathophysiology were focused on formation of hydrops followed by damage of inner ear structure and incorrectness in electrolyte transportation. Genetic studies identified a number of genes and their polymorphic variants associated with particular symptoms of Ménie`re’s disease. The findings indicate for disease heterogeneity connected with multigenic background.

keywords:

Ménière’s disease – recent literature studies on its origin

Piotr Dąbrowski 1 , Krzysztof Szyfter 2

Ménie`re’s disease, molecular pathophysiology, genetic background

Piotr Dąbrowski

¹

,

Krzysztof Szyfter

²