Contemporary Oncology
eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2025
vol. 29
 
Share:
Send email
Share:
abstract:
Case report

Microglandular adenosis associated with triple-negative invasive breast carcinoma – a case report and literature review

Aleksandra Zielinska
1
,
Mateusz Matczak
1
,
Laura Stachura
1
,
Robert Kubiak
1
,
Tomasz Michalski
2
,
Hanna Romańska
1
,
Marcin Braun
1

  1. Department of Pathology, Chair of Oncology, Medical University, Łódź, Poland
  2. Department of Oncological Gynaecology and Oncology Surgery, Copernicus Memorial Hospital, Łódź, Poland
Contemp Oncol (Pozn) 2025; 29 (2): 210–214
DOI: https://doi.org/10.5114/wo.2025.150081
Online publish date: 2025/04/30
View full text Get citation
 
PlumX metrics:
Microglandular adenosis (MGA) is a rare benign breast condition characterized by disorganized small glands composed of epithelial cells without myoepithelial components. Microglandular adenosis can coexist with invasive breast cancer (IBC), particularly the triple-negative (TN) subtype. Emerging evidence suggests MGA may be a precursor to IBC, supported by shared morphological and molecular features. We present the case of a 66-year-old woman with a palpable mass in the left breast. Initial mammography and biopsy suggested malignancy. The patient underwent breast-conserving surgery with resection of the sentinel lymph node. Histopathological analysis confirmed triple-negative, basal-like invasive breast carcinoma with focal salivary gland-type carcinoma differentiation, likely arising from an MGA-like component. The patient subsequently received adjuvant chemotherapy, and no recurrence was observed after a 30-month follow-up. This case underscores the importance of recognizing MGA as a potential precursor to invasive breast carcinoma, particularly the TN subtype. Increased awareness and the use of comprehensive diagnostic methods are essential for improving patient outcomes and managing the risks associated with MGA, especially in cases that may progress to more aggressive forms of cancer.
keywords:

microglandular adenosis, triple-negative breast carcinoma, MGA, IBC
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.