Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by motor, behavioral and cognitive symptoms. Its cause is the pathology of the tau protein encoded on the 17q21 chromosome. The article describes a 54-year-old patient who developed psychiatric disorders as the first symptoms of PSP. The patient was admitted to the Department of Psychiatry due to the deterioration of his mental state and the ineffectiveness of the therapy provided due to organic mood disorders. The patient experienced symptoms such as apathy, depression, sleep disturbances and psychomotor disturbances. The diagnosis of PSP requires the presence of clinical features and typical histopathological features. Therefore, during the life of the patient, there can be talk of a suspected or probable PSP. Cooperation with a neurologist and the clinical picture have determined the diagnosis of probable PSP.