Recent studies indicate the possibility of widespread use of light-emitting diodes (LED) in the treatment of various skin diseases. Many researchers have tried to show the mechanisms of action of different ranges of radiation generated by LED on various skin structures. LED as a non-invasive and non-thermal method may induce intracellular photobiochemical reactions stimulating fibroblast proliferation, collagen synthesis, growth factors, extracellular matrix production and skin microcirculation. Blue waves (415 nm) are effective in acne treatment. Antifungal activity of LEDs (380 nm) on Malassezia species and antibacterial activity (405 nm) have also been discovered. LED therapy is safe, and so far no adverse effects have been reported in the literature.