Lassueur-Graham-Little-Piccardi syndrome (LGLPS) is a skin disease characterized by the coexistence of progressive cicatrical head skin alopecia, non-cicatrical loss of pubic and axillary hair and lichen planopilaris. Not all of the symptoms mentioned above occur simultaneously. There are additional symptoms such as: spots and patches located on the face, trunk and limbs and typical lichen planus type of lesions. The aetiopathogenesis is not fully known yet, but relation of this syndrome to lichen planus is commonly accepted. Many authors believe that LGLPS is a variety of lichen planopilaris (LPP) as well as frontal fibrosing alopecia and classical LPP. This paper presents a case of Lassueur-Graham-Little-Piccardi syndrome in a patient with atopic dermatitis and allergic rhinitis. This case seems to be interesting as no previous evidence of coexistence of these diseases has been published. The 29-year-old patient was admitted to the hospital with progressive cicatrical head skin alopecia, loss of pubic and axillary hair and lichen planopilaris of the abdomen and back. Lassueur-Graham-Little-Piccardi syndrome diagnosis was based on the clinical symptoms and histopathological characteristics. Clinical improvement has been achieved with combined topical treatment with 0.1% tacrolimus and UVB 311 nm irradiation.