Radiotherapy is one of the most effective therapies for many different neoplasmatical diseases. It is also connected with high risk of very serious side effects, such as post-radiation skin damage (radiodermatitis). The clinical study conducted in Dolnośląskie Centrum Onkologii in Wrocław showed that application of X-ray Liposubtilium cream on the skin in the course and after finishing a radiotherapeutic session highly improves the skin’s condition, while decreasing inflammatory symptoms and skin cell damage. It also improves patients’ quality of life.