eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
1/2021
vol. 25
 
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abstract:
Short communication

Prognostic impact of microsatellite instability in gastric cancer

Cesar Zepeda-Najar
1
,
Rodrigo Xavier Palacios-Astudillo
2
,
Jazmín Danaé Chávez-Hernández
2
,
Leonardo Saul Lino-Silva
2
,
Rosa A. Salcedo-Hernández
2

1.
Surgical Oncology Division, Hospital Ángeles Tijuana, Mexico
2.
Surgical Pathology, Instituto Nacional de Cancerología de México, Mexico
Contemp Oncol (Pozn) 2021; 25 (1): 68–71
Online publish date: 2021/03/29
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Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma.

A cross-sectional study was carried out on gastric adenocarcinoma in clinical stages I to III treated with D2 gastrectomy between 2010–2013. MSI was demonstrated by immunohistochemistry. We performed a survival analysis comparing cases with and without MSI.

From 102 cases, 9.8% showed MSI. The median age was 63 years (range 33–91 years), and 57.8% were men. The more prevalent site of occurrence was the antrum (46.1%), 78.5% of the cases presented in stage III, 47.1% were of the diffuse type, 45.1% were of an intestinal type, and 7.8% were mixed. MSI cases were associated with lower clinical stages (stages I–II) and with better 5-year OS (100 vs. 47 months, p = 0.017). In a multivariate analysis, MSI was independently associated with better survival (HR = 0.209, 95% CI: 0.046–0.945, p = 0.042).

MSI gastric cancers presented in early clinical stages and had favourable prognosis compared with non-MSI cancers.
keywords:

gastric cancer, microsatellite instability, immunohistochemistry, cancer prognosis, overall survival

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