Prostaglandins in the induction of labour – do we have the optimal
substance, dose, and route of administration? Literature review

Jakub Mlodawski; Marta Mlodawska

doi:10.5114/ms.2021.107461

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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abstract:

Review paper

Prostaglandins in the induction of labour – do we have the optimal substance, dose, and route of administration? Literature review

Jakub Mlodawski

^{1, 2}

,

Marta Mlodawska

^{1, 3}

Collegium Medicum, Jan Kochanowski University, Kielce, Poland Head of the Collegium: Prof. Marianna Janion

Clinic of Obstetrics and Gynaecology, Provincial Combined Hospital, Kielce, Poland Head of the Clinic: Grzegorz Świercz PhD

Clinic of Neonatology, Provincial Combined Hospital, Kielce, Poland Head of the Clinic: Grażyna Pazera MD

Medical Studies/Studia Medyczne 2021; 37 (2): 162–167

DOI: https://doi.org/10.5114/ms.2021.107461

Online publish date: 2021/06/30

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Induction of labour (IOL) is a procedure that reduces mortality and morbidity of the mother and the newborn in particular clinical settings. Currently the number of indications for this procedure is increasing; at the same time, intensive work is underway to optimize IOL in terms of duration, obstetric results, and costs. There are no universal standards regarding the optimal way to pre-induce patients in the case of unfavourable cervix, but prostaglandin analogues play an important role in this process. In this paper we discuss the physiological role of prostaglandins and review the current evidence-based literature on this topic, trying to find optimal substance, dose, and route of administration in pre-induction of labour in terms of effectiveness, obstetrical outcomes, and intrapartum complications.

keywords:

Prostaglandins in the induction of labour – do we have the optimal substance, dose, and route of administration? Literature review

Jakub Mlodawski 1, 2 , Marta Mlodawska 1, 3

prostaglandins, misoprostol, induction of labour, cervical ripening, dinoprostone

Jakub Mlodawski

^{1, 2}

,

Marta Mlodawska

^{1, 3}