Abstract
Paclitaxel-induced pseudoscleroderma
- Dermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
- Department and Clinic of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
- Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
Introduction
Pseudoscleroderma (scleroderma-like disease) is a group of rare and chronic skin conditions that mimics systemic sclerosis. The etiology of these diseases covers a wide range of causative factors, including drugs used in chemotherapy.
Case Report
A 78-year-old woman was admitted due to significant hardening of the skin in the dorsal surface of feet and distal part of the lower legs. These lesions occurred after a concluded chemotherapy with paclitaxel for right breast cancer. Treatment with pentoxifylline, topical clobetasol and 30% urea ointment was introduced. One month later an improvement in the clinical condition was observed.
Conclusions
We present a case of pseudoscleroderma caused by paclitaxel and successfully treated with pentoxifylline and topical clobetasole. Conclusion of the treatment course with paclitaxel may have positively influenced the outcome in this treatment.
Keywords
pseudosklerodermia, paklitaksel, chemioterapia
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