QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience

Łukasz Graczyk; Robert Bibik; Antoni Woźniak; Emilia Jesień-Lewandowicz; Jacek Ciupis; Michał Szyburski; Jakub Bajer; Justyna Chałubińska-Fendler; Jacek Fijuth; Joanna Gabriela Jońska-Gmyrek

doi:10.5114/wo.2023.129462

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2023
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abstract:

Original paper

QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience

Łukasz Graczyk

¹

,

Robert Bibik

¹

,

Antoni Woźniak

¹

,

Emilia Jesień-Lewandowicz

¹

,

Jacek Ciupis

¹

,

Michał Szyburski

¹

,

Jakub Bajer

¹

,

Justyna Chałubińska-Fendler

²

,

Jacek Fijuth

³

,

Joanna Gabriela Jońska-Gmyrek

⁴

Radom Oncology Centre, Radom, Poland
Department of Radiotherapy, Military Medical Institute, Warsaw, Poland
Department of Radiation Oncology, Medical University, Łódź, Poland
Kazimierz Pulaski University of Technology and Humanities, Radom, Poland

Contemp Oncol (Pozn) 2022; 27 (2): 80–89

DOI: https://doi.org/10.5114/wo.2023.129462

Online publish date: 2023/07/21

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AMA

Graczyk Ł, Bibik R, Woźniak A, et al. QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience. Contemporary Oncology/Współczesna Onkologia. 2023;27(2):80-89. doi:10.5114/wo.2023.129462.

APA

Graczyk, Ł., Bibik, R., Woźniak, A., Jesień-Lewandowicz, E., Ciupis, J.,  & Szyburski, M. et al. (2023). QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience. Contemporary Oncology/Współczesna Onkologia, 27(2), 80-89. https://doi.org/10.5114/wo.2023.129462

Chicago

Graczyk, Łukasz, Robert Bibik, Antoni Woźniak, Emilia Jesień-Lewandowicz, Jacek Ciupis, Michał Szyburski,  and Jakub Bajer et al. 2023. "QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience". Contemporary Oncology/Współczesna Onkologia 27 (2): 80-89. doi:10.5114/wo.2023.129462.

Harvard

Graczyk, Ł., Bibik, R., Woźniak, A., Jesień-Lewandowicz, E., Ciupis, J., Szyburski, M., Bajer, J., Chałubińska-Fendler, J., Fijuth, J.,  and Jońska-Gmyrek, J. (2023). QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience. Contemporary Oncology/Współczesna Onkologia, 27(2), pp.80-89. https://doi.org/10.5114/wo.2023.129462

MLA

Graczyk, Łukasz et al. "QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience." Contemporary Oncology/Współczesna Onkologia, vol. 27, no. 2, 2023, pp. 80-89. doi:10.5114/wo.2023.129462.

Vancouver

Graczyk Ł, Bibik R, Woźniak A, Jesień-Lewandowicz E, Ciupis J, Szyburski M et al. QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience. Contemporary Oncology/Współczesna Onkologia. 2023;27(2):80-89. doi:10.5114/wo.2023.129462.

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Introduction:
The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery.

Material and methods:
Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland. Patients were treated with the Radiation Therapy Oncology Group 8502 QUAD SHOT regimen (14.8 Gy/4 fractions, twice-daily treatment with a 6 h interval, on 2 consecutive days). Courses were repeated every 4 weeks 3 times using volumetric modulated arc therapy (VMAT).

Results:
Grade 2 toxicities were observed in 4 of 9 (44.4%) patients, no grade ≥ 3 acute toxicity was observed. The median age was 79.1 (60–98) years. Irradiated areas were as follows: nose skin (2), cheek (2), eyebrow with eyelid (1), forehead (1), temple (1), sternum (1), and scapula (1). Performance status was as follows: WHO II – 5 patients (55.6%), WHO I – 3 patients, WHO III – one patient. One patient underwent 3 RT courses in 2 areas for a total of 6 treatment courses, 6 patients received 3 courses of treatment, and 2 patients received 2 courses. Additionally, as of 14 March 2023, four patients died of non-malignant causes.

Conclusions:
QUAD SHOT schedule with VMAT RT may be an effective palliative treatment method with a good response rate, which positively affects patients’ quality of life in locally advanced non-melanoma skin cancer patients disqualified from surgery.

keywords:

QUAD SHOT – an effective hypofractionated palliative radiotherapy in patients with non-melanoma skin cancer. A single-institution experience

Łukasz Graczyk 1 , Robert Bibik 1 , Antoni Woźniak 1 , Emilia Jesień-Lewandowicz 1 , Jacek Ciupis 1 , Michał Szyburski 1 , Jakub Bajer 1 , Justyna Chałubińska-Fendler 2 , Jacek Fijuth 3 , Joanna Gabriela Jońska-Gmyrek 4

QUAD SHOT, skin cancer of head and neck region, radiotherapy, hypofractionation, palliative radiotherapy

Łukasz Graczyk

¹

,

Robert Bibik

¹

,

Antoni Woźniak

¹

,

Emilia Jesień-Lewandowicz

¹

,

Jacek Ciupis

¹

,

Michał Szyburski

¹

,

Jakub Bajer

¹

,

Justyna Chałubińska-Fendler

²

,

Jacek Fijuth

³

,

Joanna Gabriela Jońska-Gmyrek

⁴