Radiation-associated sarcomatoid carcinoma of the larynx as a late complication of papillary thyroid cancer treatment
Department of Oncological Endocrinology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Department of Head and Neck Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Contemp Oncol (Pozn) 2026; 30 (3)
Data publikacji online: 2026/10/01
- El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 5th ed. IARC Press, Lyon 2022, 2022.
- Xu Z, Wang L, Tu L, Liu Y, Xie X, Tang X, et al. Epidemiology of and prognostic factors for patients with sarcomatoid carcinoma: a large population-based study. Am J Cancer Res 2020; 10: 3801-3814.
- Coca-Pelaz A, Mäkitie AA, Strojan P, Corry J, Eisbruch A, Beitler JJ, et al. Radiation-induced sarcomas of the head and neck: a systematic review. Adv Ther 2021; 38: 90-108.
- Giannini L, Incandela F, Fiore M, Gronchi A, Stacchiotti S, Sangalli C, et al. Radiation-induced sarcoma of the head and neck: a review of the literature. Front Oncol 2018; 8: 449.
- Jarząb B, Dedecjus M, Lewiński A, Adamczewski Z, Bakuła- Zalewska E, Bałdys-Waligórska A, et al. Diagnosis and treatment of thyroid cancer in adult patients – Recommendations of Polish Scientific Societies and the National Oncological Strategy. 2022 Update [Diagnostyka i leczenie raka tarczycy u chorych dorosłych – Rekomendacje Polskich Towarzystw Naukowych oraz Narodowej Strategii Onkologicznej. Aktualizacja na rok 2022]. Endokrynol Pol 2022; 73: 173-300.
- Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, et al., Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019; 30: 1856-1883.
- Cortas C, Charalambous H. Tyrosine kinase inhibitors for radioactive iodine refractory differentiated thyroid cancer. Life 2024; 14: 22.
- Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med 2015; 372: 621-630.
- Giuliani M, Brierley J. Indications for the use of external beam radiation in thyroid cancer. Oncol Clin Pract 2014; 10: 46-51.
- Kiess AP, Agrawal N, Brierley JD, Duvvuri U, Ferris RL, Genden E, et al., External-beam radiotherapy for differentiated thyroid cancer locoregional control: a statement of the American Head and Neck Society. Head Neck 2016; 38: 493-498.
- Beddok A, Morvan JB, Boudin L, da Silva Ribeiro Mota A, Dutheil P, Guilbert P, et al. the role of external beam radiation therapy in thyroid cancer management: a scoping review. Int J Radiat Oncol Biol Phys 2026; 124: 70-91.
- Singh GK, Yadav V, Singh P, Bhowmik KT. Radiation-induced malignancies making radiotherapy a “two-edged sword”: a review of literature. World J Oncol 2017; 8: 1-6.
- Chan TY, Alagappan V, Vellayappan B. Wielding a double-edged sword in head and neck cancers – diagnosis, risk factors and mitigation strategies of radiation-induced head and neck sarcomas: a narrative review. Precis Cancer Med 2021; 4.
- Bhatti P, Veiga LHS, Ronckers CM, Sigurdson AJ, Stovall M, Smith SA, et al., Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study. Radiat Res 2010; 174: 741-752.
- Völker HU, Scheich M, Höller S, Ströbel P, Hagen R, Müller- Hermelink HK, et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor – report of two cases with similar morphology. Diagn Pathol 2007; 2: 1.
- Colizza A, Gilardi A, Greco A, Cialente F, Zoccali F, Ralli M, et al. Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity. Eur Arch Otorhinolaryngol 2022; 279: 1167-1173.
- Thompson LD, Wieneke JA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 2002; 26: 153-170.
- Ding L, Bi ZF, Yuan H, Zhao XH, Guan XD, Yao HR, et al. Sarcomatoid carcinoma in the head and neck: a population-based analysis of outcome and survival. Laryngoscope 2021; 131: E489-e499.
- Viswanathan S, Rahman K, Pallavi S, Sachin J, Patil A, Chaturvedi P, et al. Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. Head Neck Pathol 2010; 4: 265-275.
- Mousli A, Friaa F, Boudhina E, Kamoun S, Abidi R, Nasr C. Spindle cell carcinomaof the larynx: a case report and literature review. Rare Tumors 2024; 16: 20363613241242705.
- Pathak S, Bindroo S, George S, Limaye S. Early and exceptional response to immunotherapy in metastatic spindle cell carcinoma of the tongue. BMJ Case Rep 2025; 18: e262570.
- Sigurdson AJ, Ronckers CM, Mertens AC, Stovall M, Smith SA, Liu Y, et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 2005; 365: 2014-2023.
- Veiga LH, Holmberg E, Anderson H, Pottern L, Sadetzki S, Adams MJ, et al. Thyroid cancer after childhood exposure to external radiation: an updated pooled analysis of 12 studies. Radiat Res 2016; 185: 473-484.
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