Raynaud phenomenon occurs as a result of the exposure to low temperatures and stress and it may affect nearly 20% of the general population. As a secondary phenomenon it coexists with connective tissue disease: systemic sclerosis, systemic lupus erythematosus and dermatomyositis. Capillary microscopy is a non-invasive method, without any risk and easy to assess microvascular abnormalities, influence of therapeutic methods and Raynaud phenomenon progression. The aim of the study was to assess, using conventional in vivo capillary microscopy, a microvascular condition and its abnormalities in nail bed in patients with diagnosed connective tissue disease (CTD). 52 female patients with diagnosed CTD had undergone clinical and capillary microscopic examinations. In the paper results of clinical and microvascular studies at the group of observed patients were reported.