Resveratrol as a factor preventing skin aging
and affecting its regeneration

Kamil Leis; Karolina Pisanko; Arkadiusz Jundziłł; Ewelina Mazur; Kaja Męcińska-Jundziłł; Henryk Witmanowski

doi:10.5114/ada.2022.117547

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Resveratrol as a factor preventing skin aging and affecting its regeneration

Kamil Leis

¹

,

Karolina Pisanko

¹

,

Arkadiusz Jundziłł

¹

,

Ewelina Mazur

¹

,

Kaja Męcińska-Jundziłł

²

,

Henryk Witmanowski

¹

Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Department of Dermatology and Venerology, Faculty of Medicine in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Adv Dermatol Allergol 2022; XXXIX (3): 439-445

DOI: https://doi.org/10.5114/ada.2022.117547

Online publish date: 2022/07/15

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Resveratrol, a compound belonging to polyphenols, besides its action on the cardiovascular system, affects also wound healing, regeneration, and photoaging of the skin. By interactions with numerous substances and pathways, e.g. MAPK, MAPKK, FOXO3, TGF or metalloproteinase 1, it protects the skin against the harmful effects of type B ultraviolet radiation, which is the main factor in the skin aging processes. It also enhances collagen synthesis by activating the oestrogen receptor and reduces wrinkles. In damaged tissues, it accelerates skin regeneration and healing by activating, among others, VEGF. Based on the review of the literature, there is no doubt that resveratrol has the potential to be used in cosmetology, dermatology and plastic surgery. It can be used as a compound of anti-aging products or as a topical treatment of scars and wounds. In the future this polyphenol might be applied in pharmacotherapy of many dermatoses.

keywords:

Resveratrol as a factor preventing skin aging and affecting its regeneration

Kamil Leis 1 , Karolina Pisanko 1 , Arkadiusz Jundziłł 1 , Ewelina Mazur 1 , Kaja Męcińska-Jundziłł 2 , Henryk Witmanowski 1

resveratrol, skin aging, skin regeneration, polyphenols

Kamil Leis

¹

,

Karolina Pisanko

¹

,

Arkadiusz Jundziłł

¹

,

Ewelina Mazur

¹

,

Kaja Męcińska-Jundziłł

²

,

Henryk Witmanowski

¹