eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Contemporary Oncology
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1A/2015
 
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abstract:

Review
Biology of renal tumour cancer stem cells applied in medicine

Damian Matak
,
Lukasz Szymanski
,
Cezary Szczylik
,
Rafal Sledziewski
,
Fei Lian
,
Ewa Bartnik
,
Anna Sobocinska
,
Anna M. Czarnecka

Contemp Oncol (Pozn) 2015; 19 (1A): A44–A51
DOI: https://doi.org/10.5114/wo.2014.47128
Online publish date: 2015/01/20
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The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies.
keywords:

tumour-initiating cells, cancer stem cells, renal cancer
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