eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
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1/2006
vol. 1
 
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Review article
Metabolic dysfunction within the anterior limbic network in bipolar disorder: a model for studying new treatments

Stephen M. Strakowski
,
Caleb M. Adler
,
Melissa P. DelBello

Neuropsychiatria i Neuropsychologia 2006; 1, 1: 5–14
Online publish date: 2006/11/27
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Bipolar disorder is a dynamic psychiatric condition that, early in its course, progresses to a recurrent and lifelong illness. Although a number of treatment options now exist, identifying effective medications for a specific bipolar individual requires trial-and-error in the absence of useful treatment response predictors. However, new imaging research suggests that bipolar disorder may result from hypermetabolism within specific brain regions constituting the anterior limbic network. This model of bipolar disorder may provide targets for monitoring treatment response and ultimately holds the promise of developing predictors of treatment response. This article provides a focused review of evidence supporting this neurophysiologic model of bipolar disorder and highlights how this model may lead to studies of medication effects and treatment response.
keywords:

bipolar disorder, functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), anterior limbic network
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