eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2011
vol. 6
 
Share:
Share:
more
 
 
abstract:

Review article
The role of glycogen synthase kinase 3β in disorders of the central nervous system

Jan K. Nowak

Neuropsychiatria i Neuropsychologia 2011; 6, 1: 25–35
Online publish date: 2011/07/14
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
The β isoform of glycogen synthase kinase 3 enzyme (GSK3β), which is found at particularly high concentrations in the central nervous system, is crucial for its proper development and functioning. The role of GSK3β in the pathogenesis of affective disorders, schizophrenia and Alzheimer’s disease, as well as its involvement in other neurological disorders and neurogenesis, is discussed. A hypothesis is proposed that inhibitory phosphorylation of GSK3β induced by non-selective cyclooxygenase (COX) inhibitors mediates the non-selective COX inhibitors’ Alzheimer’s disease and Parkinson’s disease risk-lowering effects. Throughout the review special attention is paid to the therapeutic potential of GSK3β inhibitors. Supplementary information on GSK3β cellular activity regulation, the place of GSK3β in the Wnt signalling pathway, the link between GSK3β and memory, neuroplasticity and circadian rhythms is provided.
keywords:

GSK3β, affective disorders, schizophrenia, Alzheimer disease, neurogenesis

Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe