Vitiligo is a common idiopathic depigmentary skin disorder, characterized by destruction of melanocytes, which has been reported in about 0.5-4% of the global population. The pathogenesis of vitiligo is still unclear. There are some theories regarding the mechanism of melanocyte dysfunction and disappearance (autoimmune, neural, self-destruction, oxidant and melanocytorrhagy). Treatment is difficult, prolonged and usually disappointing. An important part of therapy should involve proper education of the patient concerning not only medical methods, but also camouflage and often psychotherapy.