Combinations of topical glucocorticoids (GCs) with other substances are very often used in dermatology. One of the most common combinations is betamethasone dipropionate and salicylic acid. Betamethasone dipropionate is a potent topical glucocorticoid (belonging to class III according to the European classification) which demonstrates anti-inflammatory, anti-proliferative, immunosuppressive and vasoconstrictive properties. Salicylic acid, in turn, has a strong keratolytic and slightly antiseptic action. The use of both components in one formulation provides a significantly better GC penetration through the skin, which is crucial for the treatment of hyperkeratotic lesions.