Psoriasis is a chronic, relapsing skin disease, characterized by epidermal hyperplasia, a chronic inflammatory process, especially associated with the Th1 immune response, and local up-regulation of numerous inflammatory mediators. The pathogenesis of psoriasis is also closely associated with angiogenesis defined as formation of new capillaries from pre-existing blood vessels in psoriatic lesions. One of the most important pro-angiogenic factors is vascular endothelial growth factor (VEGF), whose concentration is elevated in the blood and skin lesions of psoriatic patients. In this review we present the role of VEGF and its receptors in psoriasis and the relation between this cytokine and genetic and immunological processes involved in the pathogenesis of psoriasis.