eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
3/2022
vol. 39
 
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abstract:
Original paper

Role of Bcl-2, p53, and Ki-67 expression in basal cell carcinoma and their association with aggressive and non-aggressive histological phenotypes

Raúl Gerardo Mendez-Flores
1
,
Diana Emilia Martínez-Fernández
2
,
Diego Ernesto Vega-De la Torre
3
,
Marianela Zambrano-Román
2
,
José Francisco Muñoz-Valle
2
,
Mario Gaston Toledo-Lelevier
1
,
Elizabeth Guevara-Gutiérrez
4
,
Marisol Ramírez-Padilla
1
,
Emmanuel Valdés-Alvarado
2

1.
Department of Dermatology, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Guadalajara, Mexico
2.
Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico
3.
Department of Pathology, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Guadalajara, Mexico
4.
Department of Dermatology, Instituto Dermatológico de Jalisco “Dr. José Barba Rubio”, Secretaría de Salud Jalisco, Zapopan Jalisco, México
Adv Dermatol Allergol 2022; XXXIX (3): 517-523
Online publish date: 2022/07/14
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Introduction
There is increasing evidence that immunohistochemical expression of p53, Ki-67, and Bcl-2 is associated with aggressive (aBCC) and less aggressive (nBCC) histological subtypes and may have a prognostic role. Aim: To investigate the clinicopathological features and immunohistochemical expressions of p53, Ki-67, and Bcl-2 in cutaneous basal cell carcinoma focusing on histological subtypes. Their roles and possible interactions in the development and progression of BCC are discussed.

Material and methods
A total of 50 BCC samples from 50 patients from Western Mexico between June 2018 and June 2019 were included. Paraffin-embedded samples were immunostained with p53, Ki-67, and Bcl-2 antibodies. Semi-quantitative analysis was performed to determine the intensity and positivity of immunostained cells. Parametrical and non-parametrical tests were performed according to the sample’s distribution.

Results
Samples included 21 nBCC and 29 aBCC. The statistical analysis showed statistical association when grouped as non-aggressive and aggressive subtypes for p53 (p = 0.04) and Bcl-2 (p < 0.01). An inverse negative correlation was found between age and Bcl-2 expression. No statistical association was found between Ki-67 immunoreactivity and any of the other variables.

Conclusions
We found that a high expression of Bcl-2 and a low expression of p53 was associated with more indolent histopathological features of BCC and therefore better outcomes. These findings suggest that examination of p53 and Bcl-2 expression in BCC patients may provide valuable prognostic information. These biomarkers may play a role in the development and progression of some cases of BCC.

keywords:

Ki-67 antigen, tumour suppressor protein p53, prognosis, BCL2 protein, human, carcinoma, basal cell

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