Abstract
Role of Vitamin D in Human Papillomavirus Infection: a Review Article
Department of Dermatology Venereology and Aesthetics, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Universitas Airlangga Hospital, Surabaya, Indonesia
Leprosy Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Dermatol Rev/Przegl Dermatol 2026, 113, 18–27
Vitamin D is a secosteroid hormone involved in multiple
physiological processes, including modulation of the innate and
adaptive immune responses and antiviral activity against DNA viruses.
Human papillomavirus infection remains a common clinical problem
due to its high prevalence and frequent recurrences. Recent studies
have investigated the potential association between vitamin D
status and susceptibility to human papillomavirus infection, as well
as the possible therapeutic role of vitamin D in diseases
associated with human papillomavirus infection. Both intralesional
and topical vitamin D have been evaluated as treatment options
in several studies, suggesting its potential use as an alternative or
adjunctive therapy. This article aims to summarize current evidence
regarding the role of vitamin D in human papillomavirus
infection and its potential therapeutic applications.
Keywords
vitamin D, human papillomavirus infection, immunotherapy
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