eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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3/2018
vol. 22
 
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abstract:
Original paper

Salivary secretory immunoglobulin A reactivity: a comparison to cortisol and -amylase patterns in the same breast cancer survivors

Maude Lambert
,
Marie-Ève Couture-Lalande
,
Kelly Brennan
,
Aldin Basic
,
Sophie Lebel
,
Catherine Bielajew

Contemp Oncol (Pozn) 2018; 22 (3): 191-201
Online publish date: 2018/09/30
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Introduction
One way to examine the extent to which the stress associated with a breast cancer experience (BC) impacts stress-related physiological mechanisms is to study the secretion patterns of associated biomarkers. Unlike cortisol and α-amylase (sAA), biomarkers of immune functioning such as secretory immunoglobulin A (SIgA) have rarely been examined in BC survivors.

Aim of the study
This study had two principal aims: the first was to evaluate the basal secretion profiles of SIgA as well as its response to an acute stressor as a marker of immune health in BC survivors and women with no history of BC, and the second was to determine how SIgA stress-related patterns compare to published cortisol and sAA patterns in the same women.

Results
Overall, the findings indicate that BC survivors exhibit a blunted cortisol reaction to an acute stressor, a generally elevated diurnal sAA concentration pattern, and normal SIgA profiles, compared to women with no history of cancer. This study serves as a foundation for future research to elucidate the relationships between BC experience variables, stress biomarkers, and health outcomes in BC survivors.

keywords:

cortisol, α-amylase, secretory immunoglobulin A, breast cancer survivorship, stress, immunity

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