eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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1/2013
vol. 17
 
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abstract:
Original paper

Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules?

Harman Ece
,
Erdogan Mehmet
,
Biray Avci Cigir
,
Dodurga Yavuz
,
Karadeniz Muammer
,
Gunduz Cumhur
,
Harman Mustafa
,
Cetinkalp Sevki
,
Saygili Fusun
,
Ozgen Ahmet Gokhan

Wspolczesna Onkol 2013; 17 (1): 51–57
Online publish date: 2013/03/15
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Aim of the study: This study aimed to evaluate 8-OHdG and hypoxia-inducible factor 1α (HIF-1α) levels in patients with hypoactive thyroid nodules (toxic multi-nodular goiter, Graves’ disease, and Hashimoto’s thyroiditis), as these parameters may be related to oxidative stress and the pathogenesis of cancer.

Material and methods: The study included patients diagnosed with Graves’ disease (n = 20), toxic multinodular goiter (n = 20), and Hashimoto thyroiditis (n = 20), and 20 healthy controls. HIF-1αα levels were measured in blood samples and 8-OHdG levels were measured in urine – both via ELISA.

Results: HIF-1α and 8-OHdG levels were significantly higher in the patient groups than in the control group (p < 0.05).

In the Hashimoto’s thyroiditis patients a correlation was observed between 8-OHdG and thyroglobulin antibodies (p = 0.03). A significant relation was found between 8-OHdG and HIF-1α in the patient group (p < 0.01). Carcinoma was detected in 7 of 43 female patients, but not in any of the male patients. No difference was observed in 8-OHdG or HIF-1α levels between the patients with and without papillary carcinoma (p > 0.05). There was no significant difference in 8-OHdG or HIF-1α levels between the patients with biopsy results that were benign, malignant, and non-diagnostic (p > 0.05).

Conclusions: Serum HIF-1α and urine 8-OHdG levels were significantly higher in the patients with thyroid diseases; however, a relationship with cancer was not observed.
keywords:

hypoactive thyroid nodule, 8-OHdG, HIF-1α

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