Full text
2/2026
vol. 113
Original article
Serum Chemerin Level as a Potential Biomarker of Early Cardiac Involvement in Patients with Psoriasis: a Case-Control Study
Dermatology, Venereology and Andrology Department, Zagazig University Hospitals, Zagazig University, Egypt
Cardiology Department, Zagazig University Hospitals, Zagazig University, Egypt
Dermatol Rev/Przegl Dermatol 2026, 113, 67–73
Data publikacji online: 2026/07/31
Article file
- Su X., Cheng Y., Zhang G., Wang B.: Chemerin in inflammatory diseases. Clin Chim Acta 2021, 517, 41-47.
- Nakajima H., Nakajima K., Nagano Y., Yamamoto M., Tarutani M., Takahashi M., et al.: Circulating level of chemerin is upregulated in psoriasis. J Dermatol Sci 2010, 60, 45-47.
- Kong S.M., Sun X.Y., Cui W.Y., Cao Y.C.: Chemerin exacerbates psoriasis by stimulating keratinocyte proliferation and cytokine production. Curr Med Sci 2023, 43, 399-408.
- Sun J.X., Zhang C., Cheng Z.B., Tang M.Y., Liu Y.Z., Jiang J.F., et al.: Chemerin in atherosclerosis. Clin Chim Acta 2021, 520, 8-15.
- Borsky P., Fiala Z., Andrys C., Beranek M., Hamakova K., Kremlacek J., et al.: C-reactive protein, chemerin, fetuin-A and osteopontin as predictors of cardiovascular risks in persons with psoriasis vulgaris. Physiol Res 2021, 70, 383-391.
- Aksu F., Caliskan M., Keles N., Erek Toprak A., Uzuncakmak T.K., Kostek O., et al.: Chemerin as a marker of subclinical cardiac involvement in psoriatic patients. Cardiol J 2017, 24, 276-283.
- Miller I.M., Ellervik C., Zarchi K., Ibler K.S., Vinding G.R., Knudsen K.M., et al.: The association of metabolic syndrome and psoriasis: a population- and hospital-based cross-sectional study. J Eur Acad Dermatol Venereol 2015, 29, 490-497.
- Schafer I., Hacker J., Rustenbach S.J., Radtke M., Franzke N., Augustin M.: Concordance of the Psoriasis Area and Severity Index and patient-reported outcomes in psoriasis treatment. Eur J Dermatol 2010, 20, 62-67.
- Lang R.M., Badano L.P., Mor-Avi V., Afilalo J., Armstrong A., Ernande L., et al.: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015, 28, 1-39.e14.
- Nagueh S.F., Smiseth O.A., Appleton C.P., Byrd B.F., Dokainish H., Edvardsen T., et al.: Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2016, 29, 277-314.
- Griffiths C.E., Barker J.N.: Pathogenesis and clinical features of psoriasis. Lancet 2007, 370, 263-271.
- Zwain A., Aldiwani M., Taqi H.: The association between psoriasis and cardiovascular diseases. Eur Cardiol 2021, 16, e19.
- Harden J.L., Lewis S.M., Pierson K.C., Suarez-Farinas M., Lentini T., Ortenzio F.S., et al.: CARD14 expression in dermal endothelial cells in psoriasis. PLoS One 2014, 9, e111255.
- Zachariae C., Skov L.: Obesity as a risk factor for psoriasis. J Eur Acad Dermatol Venereol 2020, 34, 915-916.
- Rodriguez-Zuniga M.J.M., Cortez-Franco F., Quijano-Gomero E.: Association of psoriasis and metabolic syndrome in Latin America: a systematic review and meta-analysis. Actas Dermosifiliogr 2017, 108, 326-334.
- Gerdes S., Zahl V.A., Weichenthal M., Mrowietz U.: Smoking and alcohol intake in severely affected patients with psoriasis in Germany. Dermatology 2010, 220, 38-43.
- Fan Z., Wang L., Jiang H., Lin Y., Wang Z.: Platelet dysfunction and its role in the pathogenesis of psoriasis. Dermatology 2021, 237, 56-65.
- Piaserico S., Papadavid E., Cecere A., Orlando G., Theodoropoulos K., Katsimbri P., et al.: Coronary microvascular dysfunction in asymptomatic patients with severe psoriasis. J Invest Dermatol 2023, 143, 1929-1936.e2.
- Federman D.G., Shelling M., Prodanovich S., Gunderson C.G., Kirsner R.S.: Psoriasis: an opportunity to identify cardiovascular risk. Br J Dermatol 2009, 160, 1-7.
- Garshick M.S., Ward N.L., Krueger J.G., Berger J.S.: Cardiovascular risk in patients with psoriasis: JACC review topic of the week. J Am Coll Cardiol 2021, 77, 1670-1680.
- Mariani F., Roncucci L.: Chemerin/ChemR23 axis in inflammation onset and resolution. Inflamm Res 2015, 64, 85-95.
- Chiricozzi A., Romanelli P., Volpe E., Borsellino G., Romanelli M.: Scanning the immunopathogenesis of psoriasis. Int J Mol Sci 2018, 19, 179.
- Coban M., Tasli L., Turgut S., Ozkan S., Tunc Ata M., Akin F.: Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris. Ann Dermatol 2016, 28, 74-79.
- Gisondi P., Lora V., Bonauguri C., Russo A., Lippi G., Girolomoni G.: Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol 2013, 168, 749-755.
- Helfer G., Wu Q.F.: Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol 2018, 238, R79-R94.
- Jialal I.: Chemerin levels in metabolic syndrome: a promising biomarker. Arch Physiol Biochem 2023, 129, 1009-1011.
- Tan L., Lu X., Danser A.H.J., Verdonk K.: The role of chemerin in metabolic and cardiovascular disease: a literature review of its physiology and pathology from a nutritional perspective. Nutrients 2023, 15, 2878.
- Ferland D.J., Watts S.W.: Chemerin: a comprehensive review elucidating the need for cardiovascular research. Pharmacol Res 2015, 99, 351-361.
- Inci S., Aksan G., Dogan P.: Chemerin as an independent predictor of cardiovascular event risk. Ther Adv Endocrinol Metab 2016, 7, 57-68.
- Aronis K.N., Sahin-Efe A., Chamberland J.P., Spiro 3rd A., Vokonas P., Mantzoros C.S.: Chemerin levels as predictor of acute coronary events: a case-control study nested within the Veterans Affairs Normative Aging Study. Metabolism 2014, 63, 760-766.
- Pletikosic I., Marasovic Krstulovic D., Bakovic D., Susilovic Grabovac Z., Tandara L., Martinovic Kaliterna D.: Association of inflammatory biomarkers and disease activity with subclinical myocardial dysfunction in psoriatic arthritis. Sci Rep 2023, 13, 10371.
- Rokicka D., Bożek A., Wróbel M., Nowowiejska-Wiewióra A., Szymborska-Kajanek A., Stołtny T., et al.: Identification of silent myocardial ischemia in patients with long-term type 1 and type 2 diabetes. Int J Environ Res Public Health 2022, 19, 1420.
- Zhu T.Y., Li E.K., Tam L.S.: Cardiovascular risk in patients with psoriatic arthritis. Int J Rheumatol 2012, 2012, 714321.
- Bülbül Şen B., Ekiz Ö., Rifaioğlu E.N., Bülbül F., Şen T., Kızıldağ B., et al.: Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: a speckle tracking study. Int J Dermatol 2016, 55, 158-164.
- Simsek H., Sahin M., Akyol A., Akdag S., Ozkol H.U., Gumrukcuoglu H.A., et al.: Increased risk of atrial and ventricular arrhythmia in long-lasting psoriasis patients. ScientificWorldJ 2013, 2013, 901215.
- Dikbas O., Tosun M., Bes C., Tonuk S.B., Aksehirli O.Y., Soy M.: Serum levels of visfatin, resistin and adiponectin in patients with psoriatic arthritis and associations with disease severity. Int J Rheum Dis 2016, 19, 672-677.
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