eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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SCImago Journal & Country Rank
2/2019
vol. 15
 
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abstract:
Original paper

Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study

Tomasz Roleder, Elvin Kedhi, Balazs Berta, Pawel Gasior, Wojciech Wanha, Magda Roleder, Joanna Fluder, Grzegorz Smolka, Andrzej Ochala, Wojciech Wojakowski

Adv Interv Cardiol 2019; 15, 2 (56): 143–150
Online publish date: 2019/06/26
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Introduction
To date the early strut coverage with the second-generation durable-polymer ONYX zotarolimus-eluting stent (O-ZES) is unknown.

Aim
Optical coherence tomography (OCT) assessed the strut coverage of O-ZES at thirty-day follow-up.

Material and methods
OCT was performed after implantation and at 1-month follow-up in 15 patients treated with O-ZES.

Results
Mean patient age was 67 ±7 years (73% males). The clinical presentation consisted of acute coronary syndromes (n = 13) and stable coronary disease (n = 2). Four (26%) patients had diabetes. OCT analysis was performed at baseline and 1-month follow-up in all stents. 378 cross-sections with 3582 struts were assessed at baseline and 3661 at follow-up. At follow-up, 88% struts were covered by tissue with a median thickness 37.91 µm (IQR: 22.32–64.15). Median in-stent area obstruction by neointima was 2.64% (IQR: 1.70–4.84). From the total stent covered area, 92.3% showed complete strut coverage. Homogeneous tissue was observed in 74% of cases. There were no differences in minimal lumen area (5.07 ±1.08 mm2 vs. 4.81 ±0.94 mm2, p = 0.125) or minimal stent area (4.95 ±1.22 mm2 vs. 4.92 ±0.99 mm2) at baseline and at follow-up. There were no differences in the rate of strut malapposition (4.3% vs. 5.7%, p = 0.417). For all stents, malapposition volume was 47.9 mm3 at baseline and 51.7 mm3 at follow-up, giving the late acquired stent malapposition volume of 3.8 mm3.

Conclusions
The second-generation durable polymer O-ZES showed favorable vessel healing at 30-day OCT follow-up.

keywords:

zotarolimus-eluting stent, vessel healing, optical coherence tomography, 1-month follow-up

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