eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2019
vol. 70
 
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abstract:
Case report

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis

Gábor Cserni
,
Orsolya Serfozo
,
Éva Ambrózay
,
László Markó
,
László Krenács

Pol J Pathol 2019; 70 (2): 139-143
Online publish date: 2019/09/04
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We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.
keywords:

PD-L1, spontaneous regression, tumour-infiltrating lymphocytes, triple-negative breast cancer

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