Abstract
Blood concentration of homocysteine, witamin B (12), and folic acid in exudative age related macular degeneration
- Z Zakładu Patofizjologii Katedry Patofizjologii i Endokrynologii Śląskiej Akademii Medycznej
- Z Zakładu Biochemii Klinicznej Śląskiej Akademii Medycznej
- Z Katedry i Zakładu Chemii Śląskiej Akademii Medycznej
- Z Kliniki Endokrynologii Katedry Patofizjologii i Endokrynologii Śląskiej Akademii Medycznej
Purpose
Recent studies have shown a relationship between elevated levels of Hcy and vascular disease including cerebrovascular accidents and myocardial infarctions. Elevated Hcy plasma is considered as an independent risk factor for atherosclerosis and trombosis.
Material and methods
This study included 30 patients with diagnosed exudative form of AMD. We evaluated plasma homocysteine levels, by high performance liquid chromatography and red blood cell folic acid, plasma folic acid and plasma vitamin B12 concentration by radioassay method.
Results
The plasma concentration of Hcy in AMD patients had significantly increased when compared with control group. We found not significant decrease of the plasma vitamin B12, red blood cell folic acid and plasma folic acid concentration in AMD group, when compared with the control group.
Keywords
age related macular degeneration, homocysteine, vitamin B12, folic acid