eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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SCImago Journal & Country Rank
4/2020
vol. 6
 
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abstract:
Original paper

Study of predictive factors of complete response after chemoembolization for unresectable hepatocellular carcinoma in 162 patients

El Hassani Younes
1, 2
,
Hamdoun Fatima Zahra
1, 3
,
Ben Maamar Soumaya
4
,
Lahlali Maria
1, 3
,
Lahmidani Nada
1, 3
,
Abid Hakima
1, 3
,
El Fakir Samira
4
,
Haloua Meriem
1, 2
,
Alami Badreddine
1, 2
,
Hafidi Youssef
5
,
Kamaoui Imane
6, 7
,
Boubbou Meryem
1, 2
,
Aqodad Noureddine
8, 9
,
Ibrahimi Sidi Adil
1, 3
,
Maaroufi Mustapha
1, 2
,
Alaoui Lamrani Moulay Youssef
1, 2

1.
Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco
2.
Department of Radiology, Hassan II University Hospital, Fez, Morocco
3.
Department of Hepato-gastro-enterology, Hassan II University Hospital, Fez, Morocco
4.
Epidemiology, Clinical Research and Community Health Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco
5.
Hassan II University Hospital, Central Pharmacy, Fez, Morocco
6.
Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco
7.
Department of Radiology, Mohammed VI University Hospital, Oujda, Morocco
8.
Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco
9.
Department of Radiology, Agadir University Hospital, Agadir, Morocco
Clin Exp HEPATOL 2020; 6, 4: 313–320
Online publish date: 2020/12/31
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Aim of the study
To study clinical, laboratory and imaging features correlated with complete response (CR) to transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) through 162 patients collected in Hassan II University Hospital of Fez.

Material and methods
From January 2015 to December 2019, 162 patients diagnosed with 225 HCC were treated by TACE. Among them, 14 showed CR during the follow-up. Imaging response was evaluated using the modified Response Evaluation Criteria in Solid Tumors (mRECIST). A multivariate analysis was performed including demographic parameters, etiology, -fetoprotein (AFP) rates, hepatic function scores, imaging and TACE features. In cases with complete response and remission, follow-up duration was considered from the first to the last imaging control showing no viable tumor and eventually nodule retraction.

Results
Among the 162 patients with 225 nodules, 14 (9%) of them showed remission and 148 (91%) did not. There was no significant difference between the two groups in age, performance status (PS), AFP, nodularity, size nodule or number of TACE cures. Sex, etiology, Child-Pugh and MELD scores, location, BCLC stage and blush extinction were all found to have a significant impact on therapeutic response.

Conclusions
This study demonstrates that CR of HCC treated by TACE is strongly correlated with male sex, etiology (viral hepatitis C), location (segments VI and VII) and complete blush extinction on digital subtraction angiography (DSA). No significant correlation was found, particularly that of tumor size and segment IV (as a pejorative location).

keywords:

HCC, TACE, complete response

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