Introduction

Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare neutrophilic dermatosis of sudden onset. The disease may be induced by preceding infectious diseases, coexist with autoimmune diseases, be a revelator of proliferative diseases, and also be provoked by drugs.

Objective

To present a case of a patient with Sweet’s syndrome successfully treated with prednisone and dapsone.

Case report

A forty-five-year-old man was admitted to the Department of Dermatology and Venereology for the differential diagnosis and treatment of skin lesions that had persisted for a month. Sweet’s syndrome was diagnosed on the basis of the clinical presentation and histopathology. All skin lesions resolved after tretment with prednisone and dapsone.

Conclusions

Oral glucocorticosteroids are the first-line therapy, and improvement in the local condition is observed during the first few days of treatment. Because of the possible comorbidities, which include neoplastic diseases, patients with Sweet’s syndrome require thorough work-up and long-term follow-up after treatment.