Systematic review of the stability and compatibility of propofol injection

Muftihatul Husna; Siti Z. Munawiroh; Ratna Puji Ekawati; Suci Hanifah

eISSN: 1731-2515
ISSN: 0209-1712

Anestezjologia Intensywna Terapia

Bieżący numer Archiwum O czasopiśmie Rada naukowa Recenzenci Prenumerata Kontakt Zasady publikacji prac

Panel Redakcyjny

Zgłaszanie i recenzowanie prac online

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1/2021
vol. 53

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Artykuł przeglądowy

Systematic review of the stability and compatibility of propofol injection

Muftihatul Husna

¹

,

Siti Z. Munawiroh

²

,

Ratna Puji Ekawati

³

,

Suci Hanifah

²

Department of Apotechary Program, Universitas Islam, Indonesia

Department of Pharmacy, Universitas Islam, Indonesia

Dr. Soebandi Hospital, Jember, Indonesia

Anaesthesiol Intensive Ther 2021; 53, 1: 79–88

Data publikacji online: 2021/04/02

Pełna treść artykułu Pobierz cytowanie

One ampoule of propofol is often divided into several syringes or is sometimes combined with other drugs that may lead to incompatibility and instability. A systematic review of literature (PubMed, Science Direct, and Google Scholar) identified 37 pieces of research which suggest that the data on propofol stability are limited. Results of all of the identified studies indicated that the stability of propofol is less than 24 hours.

Additionally, the evidence shows that glass packaging as well as storing in cold and dark conditions promote stability. What is more, propofol was proved to be incompatible with 23 of the 36 drugs tested. In conclusion, there is a relatively small body of literature that measures the physical stability of propofol. The findings of this review recommend keeping propofol in glass and storing it no longer than 24 hours. Compatibility data must be considered in co-administrations with propofol.

Systematic review of the stability and compatibility of propofol injection

Muftihatul Husna 1 , Siti Z. Munawiroh 2 , Ratna Puji Ekawati 3 , Suci Hanifah 2

Muftihatul Husna

¹

,

Siti Z. Munawiroh

²

,

Ratna Puji Ekawati

³

,

Suci Hanifah

²