eISSN: 2081-2833
ISSN: 2081-0016
Medycyna Paliatywna/Palliative Medicine
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4/2016
vol. 8
 
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abstract:
Review paper

Tapentadol in the treatment of tumor-related chronic pain

Tomasz Dzierżanowski
,
Aleksandra Ciałkowska-Rysz

Medycyna Paliatywna 2016; 8(4): 157–163
Online publish date: 2017/03/07
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Tapentadol is a novel analgesic of a dual mechanism of action, the first representative of the centrally acting analgesic drugs called MOR-NRI. It has the agonistic activity towards µ receptors (MOR) and non-opioid – inhibiting norepinephrine reuptake (NRI) at the spinal cord level. These two mechanisms unveil synergy, clinically confirmed in multiple kinds of nociceptive and neuropathic pain. In this paper, we described the place of tapentadol in the treatment of tumor-related pain, in comparison to other III step opioids of the analgesic ladder.
keywords:

tapentadol, chronic pain, cancer pain, opioids, Evidence Based Medicine

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