Abstract
The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part I: B7-H1 (PD-L1) and B7-DC (PD-L2)
- Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland
- Department of Pathomorphology, University of Warmia and Mazury, Olsztyn, Poland
- Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland
- Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
- Department of Oral Surgery, Medical University of Warsaw, Warsaw, Poland
- Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy
- Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy
Introduction
Oral squamous cell carcinoma (OSCC) is the most common cancerous lesion in the oral cavity. During recent years, no significant reduction in the survival rate has been observed.
Aim
To systematically review the literature and to summarise correlations between B7 family proteins and prognosis in OSCC.
Material and methods
A systematic review of the literature about B7-H1 (PD-L1) and B7-DC (PD-L2) was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-six articles published before 22 May 2020 were included in the systematic review.
Results
The biggest study group consisted of 305 patients and the smallest – 10 patients. PD-L1 proved to be a prognostic factor in patients with OSCC. Immunohistochemistry was the most commonly used diagnostic method.
Conclusions
Any mutations in the gene encoding PD-L1 and quantitative or functional changes in the status of PD-L1 may be important in the prognosis of OSCC.
Keywords
squamous cell carcinoma, oral cavity, B7 antigens
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