en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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3/2007
vol. 45
 
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abstract:

The genetic basis of ankylosing spondylitis

Anna Olewicz-Gawlik
,
Paweł Hrycaj

Reumatologia 2007; 45, 3: 137–141
Online publish date: 2007/07/02
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Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis, with less than 50% of the genetic contribution attributed to HLA-B27 and other major histocompatibility complex genes. Therefore the researcher’s interest has focused on non-major histocompatibility complex genes. The regions implicated in susceptibility to ankylosing spondylitis have been confirmed on chromosomes: 1p, 2q, 3p, 6p (major histocompatibility complex region), 6q, 9q, 10q, 16q, 17p, 19q. Despite use of modern technologies only few non-major histocompatibility complex genes responsible for the susceptibility to ankylosing spondylitis were identified, most notably in the interleukin-1 gene complex.
keywords:

genes, susceptibility, ankylosing spondylitis







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