eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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3/2017
vol. 3
 
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abstract:
Review paper

The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease

Magdalena Świderska
,
Jerzy Jaroszewicz
,
Agnieszka Stawicka
,
Anna Parfieniuk-Kowerda
,
Adrian Chabowski
,
Robert Flisiak

Clin Exp HEPATOL 2017; 3, 3: 127-134
Online publish date: 2017/06/21
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Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease, coupled with metabolic syndrome, which may progress to non-alcoholic steatohepatitis (NASH). Diabetes, obesity, hypertension, hypercholesterolemia, and hypertriglyceridemia are considered to be the most common causes leading to the incidence of NAFLD. It is assumed that the accumulation of lipid deposits in hepatocytes leads to production of proinflammatory cytokines that triggers the development of liver inflammation. Regulatory T cells (Tregs) play a critical role in regulating inflammatory processes in NASH, while T helper type 17 (Th17) might functionally oppose Treg-mediated responses. In addition, important mediators of hepatic steatosis are fatty hormones known as adipokines. We aimed to describe the significance and interaction between Treg and Th17-related cytokines as well as adipokines in pathogenesis and its potential use as biomarkers of NAFLD, especially with respect to progression to NASH.
keywords:

NAFLD, NASH, Treg, Th17, adipokines

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