The role of epidermal growth factor in psoriasis

Małgorzata Szterling-Jaworowska; Iwona Flisiak; Anna Baran; Bożena Chodynicka

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2009
vol. 96

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abstract:

Review paper

The role of epidermal growth factor in psoriasis

Małgorzata Szterling-Jaworowska

,

Iwona Flisiak

,

Anna Baran

,

Bożena Chodynicka

Przegl Dermatol 2009, 96, 435-439

Online publish date: 2009/12/29

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Psoriasis is a chronic skin disease characterized by benign proliferation of epidermal cells. The most important seems to be: excessive divisions of keratinocytes in the basal-cell layer, its abnormal maturation and increase of angiogenesis. Epidermal growth factor (EGF) is regarded as a factor playing probably the major role in pathogenesis of psoriasis. It regulates cell growth, and stimulates proliferation and differentiation through binding with the EGF receptor (EGFR). In active psoriatic lesions regular increase of EGFR expression in all layers of the epidermis is observed. Blockage of EGFR with monoclonal antibodies inhibits proliferation of keratinocytes. In this review article we present data on the importance of EGF in pathogenesis of human skin diseases, indicating the need for further studies on its role in the pathogenesis of psoriasis.

keywords:

The role of epidermal growth factor in psoriasis

Małgorzata Szterling-Jaworowska , Iwona Flisiak , Anna Baran , Bożena Chodynicka

psoriasis, growth factors, EGF, EGFR

Małgorzata Szterling-Jaworowska

,

Iwona Flisiak

,

Anna Baran

,

Bożena Chodynicka