eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2018
vol. 4
 
Share:
Share:
more
 
 
abstract:
Review paper

The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy

Tomasz Menżyk
,
Martyna Bator
,
Aleksandra Derra
,
Rafał Kierach
,
Michał Kukla

Clin Exp HEPATOL 2018; 4, 4: 217–223
Online publish date: 2018/12/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder which typically commences in the late second or third trimester and resolves within 48 hours after delivery. It is characterized by mild to severe pruritus, without any specific dermatologic features, elevated liver enzymes and increased serum bile acids (BA). The etiology of ICP is still not completely explicit. Pathogenesis includes a combination of hormonal and environmental factors superimposing on a genetic predisposition. During recent years increasingly ICP is recognized to be associated with an abnormal metabolic profile, including glucose intolerance and dyslipidemia, although it is considered to be secondary to maternal aberrant BA homeostasis. This article reviews the recent literature data and current concepts for ICP, with emphasis on a possibility of metabolic disorders being primary causative factors in ICP pathogenesis.
keywords:

intrahepatic cholestasis, pregnancy, bile acid, metabolic syndrome, irisin

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.