The significance of folate supplementation

Magdalena Pisarska-Krawczyk; Grażyna Jarząbek-Bielecka; Marek Bielecki

doi:10.5114/jhi.2016.65365

eISSN: 2450-5722
ISSN: 2450-5927

Journal of Health Inequalities

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abstract:

Review paper

The significance of folate supplementation

Magdalena Pisarska-Krawczyk

^{1, 2}

,

Grażyna Jarząbek-Bielecka

³

,

Marek Bielecki

⁴

Higher Vocational State School in Kalisz, Poland

Department of Maternal and Child Health, Poznan University of Medical Sciences, Poznan, Poland

The Clinic of Gynaecology of the Department of Perinatology and Gynaecology, The Division of Developmental Gynaecology and Sexology of the Department of Perinatology and Gynaecology, Poznan University of Medical Sciences, Poznan, Poland

“MEDICA” Pharmacy, Poznan, Poland

J Health Inequal 2016; 2 (2): 205–209

DOI: https://doi.org/10.5114/jhi.2016.65365

Online publish date: 2016/12/30

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Folates are pterin derivatives oxidised to various degrees, which exhibit the biological activity of folic acid. Physiologically, they act as coenzymes (cofactors) essential for ensuring normal metabolism, tissue renewal, and growth, particularly whenever any increasing demands arise due to accelerating cell division and metabolism. The importance of their role in organogenesis is widely recognised during pregnancy. The most common cause of folate deficiencies occurs when there are increased physiological demands for this compound, for instance: during pregnancy (especially in cases of having twins), gastrointestinal (GI) malabsorption of folate, congenital disorders of the GI tract, or if cytostatic medication has been given. Taking folate as a prophylactic measure also reduces rates of megaloblastic anaemia and neural tube defects.

keywords:

folate, supplementation, prevention

Journal published under the patronage of:

The significance of folate supplementation

Magdalena Pisarska-Krawczyk 1, 2 , Grażyna Jarząbek-Bielecka 3 , Marek Bielecki 4

folate, supplementation, prevention

Magdalena Pisarska-Krawczyk

^{1, 2}

,

Grażyna Jarząbek-Bielecka

³

,

Marek Bielecki

⁴