The suspected role of selenium in pathogenesis of rheumatoid arthritis

Edyta Olesińska; Ewa Tuszkiewicz-Misztal

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

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1/2005
vol. 43

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abstract:

The suspected role of selenium in pathogenesis of rheumatoid arthritis

Edyta Olesińska

,

Ewa Tuszkiewicz-Misztal

Reumatologia 2005; 43, 1: 31–34

Online publish date: 2005/03/14

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Selenium (Se) is an essential trace element for human health and is associated with a variety of physiological functions. Se, as selenocysteine, is a component of selenoproteins. The most well characterized selenoenzymes is the family of selenium-dependent glutatione peroxides (GSH-px). These enzymes are involved in many biochemical processes such as protection against oxidative stress. Se deficiency results in a significant decrease in GSH-px, and increase in reactive oxygen species production. Inadequate Se level can be linked to increase risk of such disease as rheumatoid arthritis, cardiomyopathy and cancer.
The aim of the article was to analyze data referring to the relationship between the selenium level and the risk of rheumatoid arthritis (RA), association of selenium concentration with disease activity and the selenium supplementation effect.

keywords:

selenium, rheumatoid arthritis, oxidative stress

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BOOKS/KSIĄŻKI

The suspected role of selenium in pathogenesis of rheumatoid arthritis

Edyta Olesińska , Ewa Tuszkiewicz-Misztal

selenium, rheumatoid arthritis, oxidative stress

Edyta Olesińska

,

Ewa Tuszkiewicz-Misztal