Clinical and Experimental Hepatology

Abstract

4/2019 vol. 5
Original paper

The usefulness of commercially available serological tests in the diagnosis and monitoring of treatment in patients with alveolar echinococcosis

Małgorzata Sulima 1
,
Beata Szostakowska 2
,
Wacław Nahorski 1, 3
,
Katarzyna Sikorska 1, 4
,
Wojciech Wołyniec 5
,
Piotr Wąż 6
  1. Department of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine (UCMTM) in Gdynia, Medical University of Gdansk, Poland
  2. Department of Tropical Parasitology, Chair of Tropical Medicine and Parasitology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Poland
  3. Department of Tropical and Parasitic Diseases, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Poland
  4. Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Poland
  5. Department of Occupational, Metabolic and Internal Medicine, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Poland
  6. Department of Nuclear Medicine, Medical University of Gdansk, Poland
Clin Exp HEPATOL 2019; 5, 4: 327–333
DOI: https://doi.org/10.5114/ceh.2019.89480
Online publish date: 2019/11/08
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Aim of the study

To assess the clinical usefulness of serological tests in the diagnosis and monitoring of treatment of patients with alveolar echinococcosis (AE).

Material and methods

The results of serological tests, i.e. Echinococcus multilocularis ELISA (Bordier Affinity Products) and Echinococcus Western Blot IgG (LDBIO Diagnostic), of 66 patients were analysed. Duration of follow-up was two years after diagnosis. In the second phase of the study 11 sera obtained from the patients undergoing surgical treatment, in whom the results of Echinococcus Western Blot IgG assay were still positive, were additionally tested with Anti-Echinococcus EUROLINE-WB (IgG) assay.

Results

Statistically significant negativization of the Echinococcus multilocularis ELISA test was observed in the group of patients who underwent radical surgery or liver transplantation. Negativization of Echinococcus Western Blot IgG assay results was observed in some patients, among both those who received conservative treatment and those who underwent surgery, but no statistically significant differences were found between treatment groups. In 54.5% of cases the Anti-Echinococcus EUROLINE-WB (IgG) test result was negative when the results of the Echinococcus Western Blot IgG assay were still positive.

Conclusions

Echinococcus multilocularis ELISA proved to be useful in assessing the activity of AE in a group of patients who underwent radical surgery or liver transplantation. The results of our study suggest that Anti-Echinococcus EUROLINE-WB (IgG) is a more dynamic test, which at the time of disappearance of AE activity becomes negative earlier.

Keywords

serology, echinococcosis, alveolar echinococcosis

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