Polish Journal of Paediatrics
en POLSKI
eISSN: 2300-8660
ISSN: 0031-3939
Pediatria Polska - Polish Journal of Paediatrics
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1/2026
vol. 101
 
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Case report

Treatment-related toxicities in acute lymphoblastic leukemia in a child with Marfan syndrome: a case report

Kinga Kwiecinska
1
,
Wojciech Czogała
1
,
Kacper Szczepan Żurek
2
,
Konrad Kaleta
2
,
Kamil Możdżeń
2
,
Agnieszka Murawska
2
,
Szymon Skoczeń
1

  1. Department of Pediatric Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland
  2. Student Scientific Club of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Cracow, Poland
Pediatr Pol 2026; 101 (1)
Online publish date: 2026/03/30
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1. Pepe G, Giusti B, Sticchi E, Abbate R, Gensini GF, Nistri S. Marfan syndrome: current perspectives. Appl Clin Genet 2016; 9: 55-65.
2. Chang JH, Poppe MM, Hua C, Marcus KJ, Esiashvili N. Acute lymphoblastic leukemia. Pediatr Blood Cancer 2021; 68: e28371.
3. Inaba H, Mullighan CG. Pediatric acute lymphoblastic leukemia. Haematologica 2020; 105: 2524-2539.
4. Duffield AS, Mullighan CG, Borowitz MJ. International Consensus Classification of acute lymphoblastic leukemia/lymphoma. Virchows Arch 2023; 482: 11-26.
5. Petersen BS, Fredrich B, Hoeppner MP, Ellinghaus D, Franke A. Opportunities and challenges of whole-genome and -exome sequencing. BMC Genet 2017; 18: 14.
6. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) v6.0 (MedDRA 28.0). Bethesda (MD): U.S. Department of Health and Human Services 2025.
7. Lehrnbecher T, Robinson PD, Ammann RA, Fisher B, Patel P, Phillips R, et al. Guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2023 update. J Clin Oncol 2023; 41: 1774-1785.
8. Hsu C, Wang J, Liao W, Chien WC, Chung CH, Tsao CH, et al. Association between malignancies and Marfan syndrome: a population-based, nested case – control study in Taiwan. BMJ Open 2017; 7: e017243.
9. Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P, et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 2023; 58: 749-754.
10. Kraemer DM, Waschke J, Kunzmann V, Wilhelm M. Veno-occlusive disease in a male patient with Marfan syndrome and common acute lymphoblastic leukemia during induction therapy. Ann Hematol 2003; 82: 444-447.
11. Maya-González C, Delgado-Vega AM, Taylan F, Lagerstedt Robinson K, Hansson L, Pal N, et al. Occurrence of cancer in Marfan syndrome: report of two patients with neuroblastoma and review of the literature. Am J Med Genet A 2024; 194: e63812. Erratum in: Am J Med Genet A 2025: e64248.
12. Obiorah IE, Upadhyaya KD, Calvo KR. Germline predisposition to myeloid neoplasms: diagnostic concepts and classifications. Clin Lab Med 2023; 43: 615-638.
13. Sharief N, Kingston JE, Wright VM, Costeloe K. Acute leukemia in an infant with Marfan’s syndrome: a case report. Pediatr Hematol Oncol 1991; 8: 323-327.
14. Bell D, Marshman D. Diffuse large B cell lymphoma in a prosthetic aortic graft. Heart Lung Circ 2017; 26: e4-e6.
15. Demir C, Bay A, Dilek I, Öner AF. Acute myeloblastic leukemia-associated Marfan syndrome and Davidoff-Dyke-Masson syndrome: a case report. Turk J Haematol 2008; 25: 198-200.
16. Papadopoulos A, Ntaios G, Kaiafa G, Girtovitis F, Saouli Z, Kontoninas Z, et al. Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia. Int J Hematol 2008; 88: 441-442.
17. Mitton B, Coutre S, Willert J, Schlis K, Porteus M, Kharbanda S, et al. A pediatric case of T-cell prolymphocytic leukemia. Pediatr Blood Cancer 2015; 62: 1061-1062.
18. Hansen MC, Haferlach T, Nyvold CG. A decade with whole exome sequencing in haematology. Br J Haematol 2020; 188: 367-382.
19. Chaosuwannakit N, Aupongkaroon P, Makarawate P. Determine cumulative radiation dose and lifetime cancer risk in Marfan syndrome patients who underwent computed tomography angiography of the aorta in Northeast Thailand: a 5-year retrospective cohort study. Tomography 2022; 8: 120-130.
20. Stubbins RJ, Korotev S, Godley LA. Germline CHEK2 and ATM variants in myeloid and other hematopoietic malignancies. Curr Hematol Malig Rep 2022; 17: 94-104.
21. Giacomazzi J, Selistre SG, Rossi C, Alemar B, Santos-Silva P, Pe- reira FS, et al. Li-Fraumeni and Li-Fraumeni – like syndrome among children diagnosed with pediatric cancer in Southern Brazil. Cancer 2013; 119: 4341-4349.
22. Karageorgos I, Mizzi C, Giannopoulou E, Pavlidis C, Peters BA, Zagoriti Z, et al. Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-­based family genomics approach. Hum Genomics 2015 J; 9: 12.
23. Lee SY, Kim HS, Jung MH, Chang S, Kim M, Youn JC, et al. Genetic predisposition in chemotherapy-induced cardiomyopathy in a 65-year-old female with metastatic breast cancer. ESC Heart Fail 2024; 11: 2410-2414.
24. Risinskaya N, Gladysheva M, Abdulpatakhov A, Chabaeva Y, Surimova V, Aleshina O, et al. DNA copy number alterations and copy neutral loss of heterozygosity in adult Ph-negative acute B-lymphoblastic leukemia: focus on the genes involved. Int J Mol Sci 2023; 24: 17602.
25. Maya‐González C, Delgado‐Vega AM, Taylan F, Lagerstedt Robin­son K, Hansson L, Pal N, et al. Occurrence of cancer in Marfan syndrome: report of two patients with neuroblastoma and review of the literature. Am J Med Genet 2024; 194: e63812.
26. Stolfi C, Troncone E, Marafini I, Monteleone G. Role of TGF-beta and Smad7 in gut inflammation, fibrosis and cancer. Biomolecules 2020; 11: 17.
27. Hinge A, Xu J, Javier J, Mose E, Kumar S, Kapur R, et al. p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Nature communications 2017; 8: 14382.
28. Bierie B, Moses HL. Transforming growth factor beta (TGF-β) and inflammation in cancer. Cytokine Growth Factor Rev 2010; 21: 49-59.
29. Peng D, Fu M, Wang M, Wei Y, Wei X. Targeting TGF-β signal transduction for fibrosis and cancer therapy. Mol Cancer 2022; 21: 104.
30. Bataller A, Montalban-Bravo G, Soltysiak KA, Garcia-Manero G. The role of TGFβ in hematopoiesis and myeloid disorders. Leuke­mia 2019; 33: 1076-1089.
31. Huang CY, Chung CL, Hu TH, Chen JJ, Liu PF, Chen CL. Recent progress in TGF-β inhibitors for cancer therapy. Biomed Pharmacother 2021; 134: 111046.
32. Van den Bulk J, de Miranda NF, Ten Dijke P. Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression. Clin Sci 2021; 135: 35-52.
33. Dander E, Palmi C, D’Amico G, Cazzaniga G. The bone marrow niche in B-cell acute lymphoblastic leukemia: the role of microenvironment from pre-leukemia to overt leukemia. Int J Mol Sci 2021; 22: 4426.
34. Tasian SK, Loh ML, Hunger SP. Philadelphia chromosome-like acute lymphoblastic leukemia. Blood 2017; 130: 2064-2072.
35. Schultz KR, Carroll A, Heerema NA, Bowman WP, Aledo A, Slayton WB, et al. Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children’s Oncology Group study AALL0031. Leukemia 2014; 28: 1467-1471.
36. Gupta S, Rau RE, Kairalla JA, Rabin KR, Wang C, Angiolillo AL, et al. Blinatumomab in standard-risk B-cell acute lymphoblastic leukemia in children. N Engl J Med 2025; 392: 875-891..
37. Bhojwani D, Sposto R, Shah NN, Rodriguez V, Yuan C, Stetler- Stevenson M, et al. Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Leukemia 2019; 33: 884-892.
38. Eggers F, Almeida JHS Jr, Lisbôa TV, Amico SC. Creep and residual properties of filament-wound composite rings under radial compression in harsh environments. Polymers (Basel) 2020; 13: 33.
39. Pandita A, Ekstrand M, Bjursten S, Zhao Z, Fogelstrand P, Le Gal K, et al. Intussusceptive angiogenesis in human metastatic malignant melanoma. Am J Pathol 2021; 191: 2023-2038.
Copyright: © 2026 Polish Society of Paediatrics. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
 
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