Postępy w Kardiologii Interwencyjnej

Triglyceride-glucose index and risk of major adverse cardiovascular events in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

  1. Department of Cardiology, Medical Faculty, Eskisehir Osmangazi University, Eskişehir, Turkey

  2. Department of Cardiology, Eskisehir City Hospital, Eskişehir, Turkey

Adv Interv Cardiol

Data publikacji online: 2026/09/07
Article file
Triglyceride-glucose.pdf
  1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
  2. Kosmas CE, Bousvarou MD, Kostara CE, et al. Insulin resistance and cardiovascular disease. J Int Med Res 2023; 51: 3000605231164548.
  3. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-23.
  4. Kurniawan LB. Triglyceride-glucose index as a biomarker of insulin resistance, diabetes mellitus, metabolic syndrome, and cardiovascular disease: a review. EJIFCC 2024; 35: 44-51.
  5. Vasques AC, Novaes FS, de Oliveira Mda S, et al. TyG index performs better than HOMA in a Brazilian population. Arch Endocrinol Metab 2011; 55: 622-9.
  6. Wang J, Huang X, Fu C, et al. Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome. Cardiovasc Diabetol 2022; 21: 187.
  7. Yu H, Tao L, Li YG, et al. Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression. Cardiovasc Diabetol 2023; 22: 130.
  8. Mao Q, Zhou D, Li Y, et al. The triglyceride-glucose index predicts coronary artery disease severity and cardiovascular outcomes in patients with non-ST-segment elevation acute coronary syndrome. Dis Markers 2019; 2019: 6891537.
  9. Zhang Y, Ding X, Hua B, et al. High triglyceride-glucose index is associated with adverse cardiovascular outcomes in patients with acute myocardial infarction. Nutr Metab Cardiovasc Dis 2020; 30: 2351-62.
  10. Wang G, Xu C, Wang J, et al. TyG index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing PCI. Sci Rep 2025; 15: 4723.
  11. Mao Q, Zhou D, Li Y, et al. TyG index and SYNTAX score in NSTE-ACS. Dis Markers 2019; 2019: 6891537.
  12. Bilgin M, Akkaya E, Dokuyucu R. et al. Prognostic value of triglyceride glucose index in ST-elevation myocardial infarction: a key predictor of mortality and thrombus burden. Diagnostics 2024; 14: 2261.
  13. Köktürk U, Önalan O, Somuncu MU, et al. Impact of triglyceride-glucose index on intracoronary thrombus burden in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Nutr Metab Cardiovasc Dis 2024; 34: 860-7.
  14. Yu B, Mo Y, Hu X, et al. TyG index is associated with quantitative flow ratio in STEMI after PCI. Front Cardiovasc Med 2022; 9: 1002030.
  15. Feng Y, Zhuo Y, Cheng H. Predictive value of circulating cardiomyocyte-specific cell-free DNA levels for heart failure risk after acute ST-segment elevation myocardial infarction. Adv Interv Cardiol 2025; 21: 565-76.
  16. Baydar O, Kilic A, Gursoy E, et al. Relationship between the TyG index and SYNTAX score 2 in NSTEMI. Cardiovasc Endocrinol Metab 2023; 12: e0277.
  17. Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J 2023; 44: 3720-826.
  18. Özkalaycı F, Karagöz A, Karabay CY, et al. Prognostic value of triglyceride/glucose index in patients with ST-segment elevation myocardial infarction. Biomark Med 2022; 16: 613-22.
  19. Smit JW, Romijn JA. Acute insulin resistance in myocardial ischemia: causes and consequences. Semin Cardiothorac Vasc Anesth 2006; 10: 215-9.
  20. Zhu Y, Li X, Yang J, et al. Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: a cross-sectional study. Cardiovasc Diabetol 2022; 21: 224.
  21. Zeng D, Wang K, Chen Z, et al. Association between TyG index and long-term prognosis of patients with ST-segment elevated myocardial infarction undergoing percutaneous coronary intervention: a retrospective cohort study. BMJ Open 2024; 14: e079279.
  22. Al-Ali SA, Alidrisi HA, Hameed A. Correlation of insulin resistance with short-term outcome in nondiabetic patients with ST-segment elevation myocardial infarction. Cureus 2022; 14 : e33093.
  23. Lazzeri C, Sori A, Chiostri M, et al. Prognostic role of insulin resistance as assessed by homeostatic model assessment index in the acute phase of myocardial infarction in nondiabetic patients submitted to percutaneous coronary intervention. Eur J Anaesthesiol 2009; 26: 856-62.
  24. Zhang Y, Ding X, Hua B, et al. High triglyceride-glucose index is associated with adverse cardiovascular outcomes in patients with acute myocardial infarction. Nutr Metab Cardiovasc Dis 2020; 30: 2351-62.
  25. Martínez-García G, Rodríguez-Ramos M, Santos-Medina M, et al. Impact of TyG index on in-hospital mortality in STEMI: results from RECUIMA registry. Gac Med Mex 2022; 158: 86-92.
  26. Di Pino A, DeFronzo RA. Insulin resistance and atherosclerosis: implications for insulin-sensitizing agents. Endocr Rev 2019; 40: 1447-67.
  27. Yu B, Mo Y, Hu X, et al. Triglyceride-glucose index is associated with quantitative flow ratio in STEMI after PCI. Front Cardiovasc Med 2022; 9: 1002030.
  28. Qu Z, Guan X. Predictive value of the triglyceride-glucose index for no-reflow phenomenon after percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction complicated by metabolic syndrome. Am J Transl Res 2024; 16: 5539-51.
  29. Mao Q, Zhou D, Li Y, et al. The triglyceride-glucose index predicts coronary artery disease severity and cardiovascular outcomes in patients with non-ST-segment elevation acute coronary syndrome. Dis Markers 2019; 2019: 6891537.
  30. Zhang P, Zhuo Y, Feng Y, Cheng H. The predictive value of the triglyceride-glucose index for five-year all-cause mortality differs between patients with acute de novo heart failure and those with acute decompensated chronic heart failure. Adv Interv Cardiol 2025; 21: 556-64.
  31. Xiong S, Chen Q, Long Y, et al. Association of the triglyceride-glucose index with coronary artery disease complexity in patients with acute coronary syndrome. Cardiovasc Diabetol 2023; 22: 56.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
without publication fees